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01.09.2019· Does general anesthesia or intravitreal injection affect neurodevelopment in children undergoing ophthalmic procedures? De Andrade LM 1, ... High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks. Lundgren P, Jacobson L, Hård AL, Al-Hawasi A, Larsson E, Gränse L, Saric M, Sunnqvist B, …
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09.12.2019· General anesthesia has been unequivocally linked to abnormal development of the central nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in vivo studies have consistently shown that exposure to GABA agonists (eg, volatile anesthetics, midazolam, and propofol) or NMDA antagonists (eg, ketamine, isoflurane, and nitrous oxide) produces dose …
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Does general... Re: Does general anesthesia affect neurodevelopment in infants and children? Rapid response to: Clinical Review State of the Art Review Does general anesthesia affect neurodevelopment in infants and children? BMJ 2019; ...
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16.01.2016· Oxygen by face mask in the RA ... of equivalence after short exposure does not rule out the possibility that longer exposure to anaesthetics may have an effect on neurodevelopment. Further trials are required before any assumptions can be made about the impact of prolonged anaesthesia exposure in infancy. Some studies have also found a …
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Does general anesthesia affect neurodevelopment in infants and children? ... General anesthesia has been unequivocally linked to abnormal development of the central nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in vivo studies have consistently shown that exposure to GABA agonists (eg, volatile anesthetics, midazolam, and propofol) or NMDA antagonists ...
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09.12.2019· General anesthesia has been unequivocally linked to abnormal development of the central nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in vivo studies have consistently shown that exposure to GABA agonists (eg, volatile anesthetics, midazolam, and propofol) or NMDA antagonists (eg, ketamine, isoflurane, and nitrous oxide) produces dose …
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09.12.2019· Read the full review for this Faculty Opinions recommended article: Does general anesthesia affect neurodevelopment in infants and children?
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29.11.2021· General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism Jianchen Cui 1,2,3,4,5† , Jiho Park 6† , Xianshu Ju 1,2,3 , Yulim Lee 1,2,3,5 , Boohwi Hong 6,7 , Jeonghoon Ahn 6 , Yoon Hee Kim 6,7 , Youngkwon Ko 6,7 , Seok-Hwa Yoon 6,7 , Chaeseong Lim 6,7 , Sun Yeul Lee 6,7 , Sung-Oh Huh 8 , Jun Young Heo 1,2,5* and Woosuk …
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Does general anesthesia affect neurodevelopment in infants and children? Mary Ellen McCann,1,2 Sulpicio G Soriano 1,2 1Department of Anesthesia, Harvard Medical School, Boston, MA, USA 2Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Boston, MA, USA Correspondence to: S Soriano [email protected] harvard.edu Cite this as: BMJ …
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Does general anesthesia affect neurodevelopment in infants and children? ... General anesthesia has been unequivocally linked to abnormal development of the central nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in vivo studies have consistently shown that exposure to GABA agonists (eg, volatile anesthetics, midazolam, …
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16.02.2019· Brief infant general anesthesia leaves neurodevelopment unaffected. McCann ME & al. Lancet 16.02.2019
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09.12.2019· Export article. BibTeX; Endnote; RIS; Comment of this article: GA is neurotoxic in children? Does general anesthesia affect neurodevelopment in infants and children? Mary Ellen McCann, Sulpicio G Soriano . Published: 9 December 2019. by BMJ. in BMJ. BMJ, Volume 367; doi:10.1136/bmj.l6459 . Publisher Website. PubMed. Full-Text. PDF via Unpaywall. Google Scholar. …
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Anestesia general en niños pequeños Si bien se han documentado trastornos neurocognitivos por anestésicos generales en modelos de laboratorio, existe poca evidencia clínica que respalde la neurotoxicidad en niños. British Medical Journal, 9 de diciembre de 2019. anestesia general anestesia pediátrica desarrollo neurocognitivo Resumen. La anestesia general se ha …
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25.07.2020· The neurotoxicity of general anesthesia to the developing human brains is controversial. We assessed the associations between surgery under general anesthesia in infancy and development at age 1 year using the Japan Environment and Children’s Study (JECS), a large-scale birth cohort study. In the JECS, 103,062 pregnancies and 104,065 fetuses were enrolled between January 2011 and …
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29.06.2020· MASK studies indicated that single average 45 min exposure does not affect gross neurodevelopment, while multiple exposure with average of 187 min period caused the deficits in fine motor skills. Current results do not provide data regarding to the neurocognitive risks of repeated episodes of anesthesia exposure or more prolonged durations of a single exposure which often …
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12.12.2019· Does general anaesthesia affect neurodevelopment in infants and children? This review examines evidence for neurocognitive and functional effects of commonly used anesthetics in paediatric patients. It confirms that although general anaesthetics have potential to induce neurotoxicity, there is little evidence of long term anaesthetic neurotoxicity.
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Does general anesthesia affect neurodevelopment in infants and children? Abstract. General anesthesia has been unequivocally linked to abnormal development of the central nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in vivo studies have consistently shown that exposure to GABA agonists (eg, volatile anesthetics, midazolam, and propofol) or NMDA ...
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02.05.2018· While the vast majority (94%) of children undergoing general anesthesia are exposed for <3 hours, certain groups may be at increased risk for longer exposures. These findings may help guide the design of future trials aimed at understanding neurodevelopmental impact of prolonged exposure in these high‐risk groups. Citing Literature
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08.04.2015· Effect of general anesthesia on non-neuronal cells While its neurotoxic effects on neurons in the cortex and hippocampus have been well-characterized, general anesthesia also impairs other cell types aside from neurons, such as oligodendrocytes and astrocytes ( Brambrink et al., 2012 ; Culley et al., 2013 ; Ryu et al., 2014 ).
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Neurodevelopment after general anaesthesia in infants Concerns about anaesthesia-related neurological injury in young children have been increasing among parents, health-care providers, and regulatory organisations. These concerns were first prompted by animal studies that showed accelerated apoptosis and neuronal death after exposure to general anaesthetic drugs.1 Most commonly used …
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